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Indocyanine green angiography is a technique that is superior for imaging the choroidal circulation. Fluorescein diffuses out of the choriocapillaris, creating a diffuse background fluorescence. As opposed to fluorescein, indocyanine green is a larger molecule that binds completely to plasma proteins, causing it to remain in the choroidal vessels. Thus, largerchoroidal vessels can be imaged. Unique photochemical properties allow the dye to be transmitted better through melanin, blood, exudates, and serous fluid. This technique therefore serves as an important adjunct to fluorescein angiography for imaging occult choroidal neovascularization and other choroidal vascular abnormalities.
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