A cryo surgical instrument is a device used to destroy nervous tissue or produce lesions in nervous tissue by the application of extreme cold to the selected site.

Cryogenic freezers offer a dependable, cost-effective and safe alternative to liquid nitrogen vapor for long-term storage of biological at cryogenic temperatures. It maintains a uniform -140 °C or -150 °C temperature throughout the inner chamber. Cryogenic freezers utilize a patented unique single compressor refrigeration system to achieve and maintain uniform -140 °C and -150 °C temperatures.

A Cryostat is a vessel, similar in construction to a vacuum flask used to maintain cold cryogenic temperatures. Three common types of cryostat exist, the MRI (Magnetic Resonance Imaging for Clinical imaging) magnet type, the MR research magnet type and a biological microtome type. Cryostats used in MRI machines are designed to hold a liquid cryogen typically liquid Helium in a liquid state with minimal boil off (evaporation). The liquid helium bath is designed to keep the superconducting magnets bobbin of superconductive wire in its superconductive state. Typically cryostats are manufactured with two vessels, one inside the other. Those used in MRI are built with an outer evacuated vessel, and an inner or, liquid helium vessel. The outer vessel serves as a thermal insulator as well as a thermal sink or heat removal device. The use of a coldhead and a cryocooler combination, removes thermal energy away from the outer vessel, thereby presenting an even cooler stage to the inner vessel maintaining the cryogenic stability of the inner vessel. In biology, cryostats are used for freezing specimens for sectioning and staining for microscopical examination, a type of Microtome. Specimens that are soft at room temperature need to be frozen before sectioning.

Cryosurgery is a technique for freezing and killing abnormal cells. It is used to treat some kinds of cancer & some precancerous or noncancerous conditions and used both inside the body & on the skin. Cryosurgery is an alternative to surgery for liver cancer, prostate cancer and precancerous condition of the cervix. Cryosurgery is the use of extreme cold produced by liquid nitrogen to destroy abnormal tissue. Cryosurgery is used to treat external tumors. It reduces the risk of joint damage when compared with more extensive surgery and helps lessen the need for amputation.