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Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH), which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. It is often referred to as the stress hormone as it is involved in the response to stress. It increases blood pressure, blood sugar levels and has an immunosuppressive action.


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